Chats with an AI

What's the current situation with ?

It looks like you might be referring to “Celebrix,” but that name doesn’t match any major company, product, or widely‑reported news topic right now. If you meant Celebrex (which is celecoxib, a well‑known nonsteroidal anti‑inflammatory drug), here’s the current situation based on recent and reliable information:

1. Celebrex (celecoxib) remains an actively used prescription NSAID
It’s approved and regularly prescribed to treat pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile idiopathic arthritis in children aged 2 years and older, and menstrual pain/cramps. It’s taken orally and works by selectively inhibiting the COX‑2 enzyme to reduce inflammation and pain.

2. Ongoing research into new uses and combinations
Recent studies have looked at how celecoxib, often under the brand name Celebrex, might provide additional benefits beyond routine pain relief. For example, small early research in animal models showed that combining celecoxib with another compound (like low‑dose THC) might help reduce inflammation and markers of Alzheimer’s‑type pathology in mice, which could lead to future human clinical trials — but this is still experimental and not an approved treatment.

3. Role in cancer therapy research
Some clinical studies have suggested that adding celecoxib to chemotherapy for certain cancers (like stage 3 colorectal cancer) may improve outcomes for patients with detectable residual disease after surgery. This is an emerging area of research and not yet standard practice everywhere; it’s typically applied in specific clinical trial settings.

4. Safety profile and cautions remain important
Celecoxib, like all NSAIDs, carries a known risk profile. These include potential cardiovascular risks (such as increased heart attack or stroke risk), gastrointestinal issues, and kidney or liver effects. Healthcare providers generally advise using the lowest effective dose for the shortest feasible period and evaluating individual risk factors before prescribing.

5. Generic availability and production updates
Celecoxib is widely available as both the branded drug Celebrex and generic versions. Pharmaceutical manufacturers have received regulatory approvals to produce celecoxib in various dosages, which helps maintain broad access.

If you literally meant “Celebrix” as something other than the drug Celebrex/celecoxib, let me know — I could look up whether it’s a company name, product, or something else entirely and give you the latest available info.

Your link refers to "increased risk" of a bunch of things, including heart attack. That is way too vague to mean anything. Can you provide more detail?

Sure — here’s a clearer, **more specific breakdown of what the evidence says about the “heart attack/stroke risk” with Celebrex (celecoxib) — including actual numbers and context so it’s not just vague phrasing.

1) There is a measurable risk, but it’s not huge for most people

Studies have found that celecoxib can raise the chance of heart attack or stroke compared with taking nothing (placebo), especially:

In large placebo‑controlled analyses, people on celecoxib had a ~1.6‑fold higher risk (hazard ratio ~1.6) of composite cardiovascular outcomes (heart attack, stroke, heart failure, thromboembolic events) compared with placebo over several years. That means about 60% higher relative risk, not an absolute doubling of actual events — but the absolute increase is still modest because the baseline rate is low. This effect also increased with higher doses and longer use.
In a meta‑analysis of randomized trials, the odds of nonfatal heart attack were ~1.9‑2.3 times higher on celecoxib compared with placebo, though confidence intervals vary and other outcomes like stroke weren’t always statistically increased.

⚠️ Important nuance: “2× the risk” doesn’t mean everyone has a 2× risk of heart attack — it means the relative risk increases. If baseline risk is very low (e.g., 1 in 1,000), doubling it still leaves it low (2 in 1,000). Researchers look at relative risk and absolute risk separately.

**2) At usual prescription doses, recent large trials show celecoxib is similar to other NSAIDs**

A large modern trial (the PRECISION trial) directly compared celecoxib with prescription doses of ibuprofen and naproxen in patients needing chronic NSAIDs who also had cardiovascular risk:

Primary cardiovascular events (heart attack, stroke, death) occurred in 2.3% with celecoxib, 2.5% with naproxen, and 2.7% with ibuprofen — differences were not statistically significant.

This means that for people who need NSAIDs long‑term, celecoxib doesn’t appear to be worse than common others like ibuprofen or naproxen in terms of major cardiovascular events.

3) The risk depends strongly on dose, duration, and individual risk factors

Higher doses (e.g., above common prescription levels like 200 mg/day) and longer use are associated with more cardiovascular risk.
People with pre‑existing heart disease, hypertension, diabetes, kidney issues, or older adults have a higher absolute risk of these events.
Celecoxib causes fluid retention and raises blood pressure in some, which can further stress the cardiovascular system, particularly in people with heart failure or atrial fibrillation.

4) Regulatory guidance reflects these risks

Celecoxib carries a black‑box warning (the FDA’s strongest safety warning) for risk of heart attack and stroke, just like other NSAIDs.
Health authorities recommend using it at the lowest effective dose and for the shortest duration necessary, especially in people with cardiovascular risk.

Putting it in perspective

The overall absolute increase in risk for a typical patient taking celecoxib at common doses is small — just a few additional events per thousand users — but it becomes more relevant if you have heart disease or use it long‑term.
Compared to other NSAIDs, celecoxib doesn’t appear worse and may even be safer for the stomach, though all NSAIDs share some cardiovascular risk.

Summary (safest takeaway):
Celecoxib can slightly increase the risk of heart attack or stroke relative to taking no NSAID, especially at higher doses or long‑term use, and in people with existing cardiovascular risk. However, at common therapeutic doses it doesn’t seem to cause much more cardiovascular harm than other NSAIDs like ibuprofen or naproxen. Doctors use this information to balance benefits vs. risks when deciding on whether and how to prescribe it.

If you want, I can go deeper into the absolute risks (numbers per year per 1000 people) stratified by age and heart disease status — that makes the effects even easier to interpret.

What about a ?

A periodic cortisone shot (technically a corticosteroid injection, often methylprednisolone, triamcinolone, or similar) is commonly used to reduce localized inflammation and pain, especially in joints like the knee, shoulder, or spine. Here’s a clear picture of the current understanding:

1. How it works

Corticosteroids are powerful anti-inflammatory drugs. When injected directly into a joint, tendon sheath, or bursa:

They suppress the immune response locally, reducing inflammation.
Pain relief often occurs within a few days and can last weeks to months.
Unlike oral NSAIDs, the systemic exposure is much lower, so overall heart or kidney risk is smaller, though not zero.

2. Frequency limits

Repeated injections can be harmful if given too often. Most guidelines suggest no more than 3–4 injections per joint per year, sometimes fewer depending on the joint and underlying disease.
Frequent injections can cause:
- Joint cartilage weakening (potentially accelerating osteoarthritis)
- Tendon weakening or rupture
- Localized skin thinning or pigmentation changes
- Temporary systemic effects, like elevated blood sugar, fluid retention, or mood changes

3. Systemic risks

A single injection is usually safe for most people.
Repeated injections can cause mild systemic effects, especially in people with diabetes (blood sugar spikes) or those with osteoporosis (bone density loss).
Cardiovascular risk is generally much lower than long-term NSAIDs or high-dose oral steroids.

4. Practical use

Often reserved for flare-ups that haven’t responded to NSAIDs, physical therapy, or lifestyle measures.
Works best in specific joints rather than widespread pain.
Sometimes combined with other treatments like physical therapy or hyaluronic acid injections.

5. Bottom line

Periodic cortisone shots can be a safe, effective way to manage joint pain if used sparingly.
They don’t carry the same cardiovascular risks as NSAIDs, but overuse can damage joints and cause systemic side effects.
Careful scheduling and monitoring with your doctor is key.

If you want, I can compare long-term NSAIDs vs periodic cortisone injections for something like osteoarthritis, so you can see the risk/benefit profile side by side. That often helps in deciding which approach is safer for someone in their 80s.

I had typed Celebrex, and my spell checker wanted what you saw??

Ah, that makes sense — your spell checker probably tried to “correct” Celebrex and suggested Celebrix, which isn’t a real drug or product. Spell checkers can be… overzealous, especially with brand names or less common words. It looks like it misread the “‑re” as “‑ri” and just auto-suggested something that looks like a plausible word.

So we’re really talking about Celebrex (celecoxib), the NSAID, not anything called “Celebrix.”

If you want, I can give a quick, plain-language comparison between Celebrex and periodic cortisone shots for joint pain in someone your age — it’s interesting how the risks and benefits line up.

In fact it's for one of the other older Americans living here. I take an Ibuprofen now and then when my broken toe acts up, but just one with a . He was a strong badminton player and coach for many years. Now has constant pain in knees when walking.

Got it — that context helps a lot. For someone who used to be athletic and now has chronic knee pain, the choices often come down to oral NSAIDs like Celebrex, short-term use of over-the-counter NSAIDs like ibuprofen, or periodic cortisone injections — each with trade-offs, especially at an older age.

Here’s a focused comparison:

1. Oral NSAIDs (Celebrex or occasional ibuprofen)

Pros: Reduce inflammation and pain throughout the day; convenient; Celebrex is gentler on the stomach than standard NSAIDs.
Cons: Even Celebrex has some cardiovascular risk, particularly with long-term use or higher doses. It also can affect kidneys if used chronically, especially in older adults.
Tip: Using Famotidine with occasional ibuprofen, as you do, helps protect the stomach. For someone older, regular check-ins on blood pressure, kidney function, and heart status are wise.

2. Periodic cortisone injections

Pros: Can provide targeted pain relief for weeks to months, often more dramatic than oral NSAIDs for a specific joint. Systemic effects are limited if injections are spaced out.
Cons: Repeated injections can weaken cartilage and risk joint damage if overused. Usually limited to 3–4 times per joint per year. Temporary side effects (blood sugar spike, fluid retention) can happen.

3. Lifestyle and supportive measures

Even in older adults, certain measures can help:

Low-impact exercise: Swimming, stationary cycling, or gentle yoga keeps knees mobile without pounding joints.
Weight management: Every few pounds lost reduces knee load.
Supportive footwear or braces: Can relieve stress on knee cartilage.
Physical therapy: Strengthening surrounding muscles stabilizes the joint and often reduces pain.

Putting it together

For constant knee pain in an older adult, many doctors start with oral NSAIDs (Celebrex) if tolerated, combined with non-drug measures, and reserve periodic cortisone shots for flare-ups in specific joints.
The key is moderation — avoid long-term high-dose NSAIDs, and space cortisone injections properly.
Since he’s older and has chronic pain, a short consultation with a rheumatologist or orthopedic specialist could help tailor the best combination safely.

If you like, I can outline a practical weekly or monthly “pain management approach” for someone like him — showing where Celebrex, occasional ibuprofen, and cortisone shots might fit safely. That often makes the decision easier.

Any reaction with ?

Good question — for someone taking Metformin (common in older adults with type 2 diabetes), here’s what the evidence says about combining it with Celebrex (celecoxib) or occasional ibuprofen:

1. Celebrex (celecoxib) + Metformin

No direct, serious drug interaction is reported in standard references.
Caution: NSAIDs like celecoxib can, in some cases, reduce kidney function, especially in older adults or those with pre-existing kidney issues. Metformin is cleared by the kidneys, so any decline in kidney function can increase the risk of Metformin accumulation, which is dangerous (rarely leading to lactic acidosis).
Practical takeaway: If kidney function is normal, occasional Celebrex use is generally safe, but monitor kidney function (creatinine/eGFR) regularly if taken long-term.

2. Ibuprofen + Metformin

Similar story: no direct interaction, but chronic or high-dose ibuprofen can stress the kidneys.
Short-term, occasional use (like your single pill with Famotidine for a broken toe) is generally safe in someone with normal kidneys.

3. Cortisone injections + Metformin

No significant interaction.
The main caution is that corticosteroids can temporarily raise blood sugar, which may require adjusting Metformin or monitoring glucose closely for a day or two after the injection.

Summary:

No major drug-drug reactions between Metformin and Celebrex, ibuprofen, or cortisone injections.
Kidney function and blood sugar are the main things to watch.
For older adults with chronic pain and diabetes, doctors often recommend the lowest effective NSAID dose, occasional use, and periodic lab checks.

If you want, I can make a small “safety checklist” for managing knee pain in older adults on Metformin — showing what to watch for with NSAIDs, cortisone shots, and monitoring. That often makes it easier for someone to manage safely at home.

Not diabetic, not even pre-diabetic, just "on the edge."

Ah, that clarifies things — if he’s not actually diabetic, Metformin is probably being used preventively because he’s “on the edge” of elevated blood sugar or insulin resistance. That slightly changes the risk picture:

Kidney caution still matters, but the stakes are lower than in someone with established diabetes. NSAIDs (Celebrex, ibuprofen) still have the same potential to stress kidneys in older adults, but the interaction with Metformin is less worrisome because he won’t have high baseline blood sugar that could be complicated by Metformin accumulation.
Blood sugar spikes from cortisone injections are mostly only relevant if he were diabetic; otherwise they’re mild and short-lived.

So in practical terms: for an older, otherwise healthy but “borderline” person, the main issues with NSAIDs or cortisone shots remain kidney function, cardiovascular risk, and joint/cartilage health, rather than any Metformin-specific problem.

If you like, I can sketch a balanced approach for his knee pain that mixes occasional NSAIDs, potential cortisone shots, and lifestyle measures — tailored for someone his age, history, and “on the edge” metabolic status.

Returning to this issue, is there a tradeoff between the apparently small risk of serious side effects and the benefit of reducing inflammation and thereby slowing joint deterioration?

Yes — that is exactly the tradeoff clinicians consider when deciding on long-term NSAID or anti-inflammatory therapy for osteoarthritis or chronic joint pain. Here’s how it breaks down, in a nuanced, realistic way:

1. The benefit: slowing inflammation and joint damage

Osteoarthritis pain is not just a nuisance; inflammation itself contributes to cartilage breakdown.
NSAIDs like Celebrex can reduce this inflammation, which may preserve joint function for a longer time, especially in someone who is active or used to high joint demands.
Cortisone injections also dramatically reduce local inflammation, often giving weeks to months of improved mobility and less pain, which can allow exercise and muscle strengthening, further protecting the joint.

2. The risks: cardiovascular, kidney, and joint-specific

Cardiovascular risk: Small but measurable. For a generally healthy older adult with no heart disease, the absolute risk increase is low — maybe a few extra events per thousand people per year.
Kidney function: NSAIDs can stress kidneys, especially with chronic use or dehydration, which is more relevant for older adults.
Joint damage with cortisone: Repeated injections can weaken cartilage or tendons over time. The effect is localized, so spacing injections appropriately (3–4 times per year max) mitigates the risk.
Other side effects: GI upset, mild fluid retention, occasional blood pressure rise. These are usually manageable with standard precautions (Famotidine, monitoring, low effective doses).

3. Putting it in perspective

The absolute risk of serious systemic complications from judicious NSAID use is generally smaller than the risk of progressive disability from uncontrolled inflammation, especially in someone with constant knee pain.
In other words, moderate, carefully monitored anti-inflammatory therapy can provide meaningful functional benefit without greatly increasing serious health risks — particularly if you:
1. Use the lowest effective NSAID dose for the shortest necessary duration.
2. Consider periodic cortisone injections for flare-ups rather than daily high-dose oral NSAIDs.
3. Monitor kidney function and blood pressure periodically.
4. Support joint health with low-impact exercise and weight management.

4. The subtle point

The tradeoff isn’t absolute — it’s personalized. Someone with prior heart attack, chronic kidney disease, or poorly controlled hypertension would tilt the risk side upward, making NSAIDs more dangerous. But for a reasonably healthy older adult, the functional gain from reducing inflammation often outweighs the small absolute risk of serious side effects, especially if the treatment strategy is cautious and monitored.

If you want, I can draft a practical, real-world regimen showing how NSAIDs and cortisone injections could be alternated safely over a year for someone like him, balancing pain relief, mobility, and minimal systemic risk. This usually helps in making the tradeoff concrete.

If one uses Famotidine in conjunction, should it be before or with?

For Famotidine (a stomach acid–reducing H₂ blocker) used to protect the stomach when taking an NSAID like ibuprofen or Celebrex, timing is flexible, but there are some practical points:

Before or with the NSAID: Most guidelines say taking Famotidine 30–60 minutes before the NSAID gives slightly better protection because the acid suppression is already active when the NSAID hits the stomach.
With the NSAID: Taking them together is still effective — Famotidine starts working fairly quickly, and the difference is usually modest for occasional use.
Consistency matters more than exact timing: If someone is taking NSAIDs regularly, a consistent schedule (e.g., morning and evening doses) is more important than whether it’s 10 minutes before or with.

Practical example:

If he takes one ibuprofen pill for a flare, taking Famotidine 30 minutes before or at the same time is sufficient to reduce stomach irritation.
For longer-term Celebrex use, he could take Famotidine once or twice daily, usually in the morning and evening, depending on the dose, independent of the NSAID timing.

If you want, I can outline a simple routine showing NSAID plus Famotidine timing for occasional pain vs longer-term use — it helps keep it safe without overcomplicating things.

I personally take a Famotidine on evenings when I feel a little heartburn, supplemented later with calcium carbonite if necessary.

That’s a sensible, mild approach — using Famotidine as needed for heartburn and supplementing with calcium carbonate (Tums or similar) if symptoms persist. It keeps acid suppression limited to when it’s needed and avoids unnecessary daily dosing, which is fine for someone without chronic NSAID use.

A few points to keep in mind if this strategy continues:

Famotidine works within an hour, and its effect lasts about 10–12 hours. Taking it in the evening covers nighttime acid production, which is often when heartburn hits.
Calcium carbonate acts almost immediately to neutralize acid, so it’s ideal as a backup if heartburn flares after dinner or at night.
NSAID timing: If you were taking an NSAID occasionally (like ibuprofen for your toe), taking Famotidine shortly before or with it ensures stomach protection. Your existing evening habit wouldn’t conflict unless you were taking NSAIDs at a different time of day.
Long-term calcium intake: If using calcium supplements frequently, keep an eye on daily total calcium to avoid exceeding recommended limits (generally around 1,000–1,200 mg/day for older adults), since excess can contribute to kidney stones in some people.

Overall, your routine is cautious and balanced for mild symptoms — it just needs a small adjustment if NSAIDs are taken for pain flares, mainly to take Famotidine close to the NSAID dose.

If you want, I can suggest a very simple “as-needed” schedule for occasional NSAID use plus your current heartburn meds that keeps it safe and effective.

I avoid Tums because of the sugar and instead use a local product that needs to be ground into a powder. Little dairy here, maybe a slice of American cheese each fortnight. Not listed in my supplement.

That makes sense — in a low-dairy setting, using a sugar-free local antacid is smart, especially if you’re monitoring sugar intake and don’t get much calcium from diet. Grinding the powder yourself is a bit more work, but it works the same as Tums in neutralizing stomach acid.

A few notes given your situation:

Calcium intake is very low with only occasional cheese and no supplements. Over the long term, this could affect bone density, especially in someone older or with limited mobility. You might want to consider a small, low-dose calcium supplement if diet can’t provide enough. Even 200–300 mg/day is better than nothing.
NSAID use: Occasional ibuprofen with Famotidine is safe for your stomach, and your current antacid can supplement that if a flare-up causes discomfort.
Absorption timing: If you ever start a calcium supplement, separate it from high-dose antacids, because aluminum/magnesium in antacids can interfere with calcium absorption.

So your current regimen is safe for occasional NSAID use, but bone health could be a longer-term consideration given minimal dietary calcium.

If you like, I can suggest a practical “low-dairy, older adult bone support” plan that fits your environment and avoids sugar-heavy products.

I do get about three each day.

Ah — that actually makes a significant difference! Whole sardines are a very good source of calcium, vitamin D, and protein, especially if you eat the bones (which is where most of the calcium is). Just three sardines a day can provide roughly 200–300 mg of calcium, depending on size, plus some vitamin D, which helps your body use that calcium for bone health.

So combined with your occasional cheese, your dietary calcium intake is modest but not negligible, and your risk of deficiency is lower than I initially suggested. A few points to keep in mind:

Absorption is best with meals, so having the sardines with a main meal is ideal.
Vitamin D status matters: If sun exposure is limited, you might still consider a small vitamin D supplement, since older adults absorb calcium less efficiently.
NSAID use: Your occasional ibuprofen plus sardine calcium doesn’t pose a conflict — no special adjustments are needed.
Bone protection: Combined with low-impact exercise and avoiding falls, this intake is probably adequate to help maintain bone strength at your age.

If you want, I can give a rough estimate of your daily calcium and vitamin D intake from sardines plus your other foods, to see how close you are to recommended levels for older adults.

And of course I'm on that weekly bone pill; have been a couple years since the serious fall, although no bones were broken then.

Perfect — that fits together nicely. That weekly bone pill (likely a bisphosphonate, such as alendronate) is exactly the kind of long-term therapy used to strengthen bone and reduce fracture risk after a fall, even when no bones were broken. Combined with your dietary calcium from sardines, occasional cheese, and any incidental calcium from the local antacid, plus weight-bearing or low-impact movement, your bones are getting solid support.

A couple practical notes:

Take the bone pill exactly as prescribed (usually on an empty stomach with water, staying upright for at least 30–60 minutes) — that’s important for absorption and to avoid esophageal irritation.
Keep your fall-prevention measures (grab bars, careful footing) in place — drugs plus environment together give the best protection.
Your occasional NSAID use or cortisone injections for joint pain generally don’t interfere with bisphosphonates, so you can safely manage knee pain without undermining your bone therapy.

All in all, your regimen seems well-structured: bone-strengthening meds, modest dietary calcium, sardines for protein and calcium, and careful monitoring of joint pain. It’s a nice balance of safety and functional mobility.

If you like, I can suggest a very practical routine for maintaining knee comfort and bone health simultaneously, so you can see how NSAIDs, cortisone injections, sardines, and your weekly pill fit together safely.

Let's keep it straight: the knee pain is 's complaint and he is the one considering cortisone injections.

Got it — thanks for clarifying. So we’re focusing on Sunny’s chronic knee pain and the decision about whether periodic cortisone injections (or possibly Celebrex/NSAIDs) make sense for him. Your regimen is separate, just occasional ibuprofen for your toe with Famotidine, plus your weekly bone pill and dietary calcium.

For Sunny, here’s a clear summary of considerations:

1. Benefits of cortisone injections

Can dramatically reduce knee inflammation and pain for weeks to months.
Allows for better mobility and exercise, which can indirectly help maintain joint function.
Localized, so systemic side effects are usually minimal compared to oral NSAIDs.

2. Risks

Repeated injections can weaken cartilage or tendons if overused. Guidelines usually suggest no more than 3–4 injections per joint per year.
Temporary blood sugar rises (if he were diabetic — less relevant if he isn’t).
Mild swelling or discomfort at the injection site.

3. Oral NSAIDs (Celebrex, ibuprofen)

Reduce inflammation systemically, which can also slow joint deterioration to some extent.
NSAIDs carry small cardiovascular or kidney risks, more relevant with long-term use.
Can be paired with stomach protection (like Famotidine) if needed.

4. Lifestyle support

Low-impact exercise, joint-strengthening, weight management, and supportive footwear help reduce pain and slow deterioration.
Avoiding falls or high-impact activity protects already stressed knees.

Summary: For someone like Sunny, the tradeoff is straightforward: periodic cortisone injections can give meaningful relief and functional gain, with low systemic risk if spaced appropriately. Long-term daily NSAIDs carry more systemic risk, though moderate Celebrex use can be safe under monitoring. Lifestyle measures always complement both approaches.

If you want, I can draft a practical, realistic plan for Sunny showing how cortisone injections, NSAID use, and exercise could be combined safely to manage his knee pain over the year.